Products > Arterial Measurement > PulseTrace Validation and Bibliograpy
The Digital Volume Pulse (DVP) is 'the same' as the pressure pulse in the wrist
It has been known for some time that the peripheral pressure pulse contains information on arterial stiffness and vascular tone and that increased arterial stiffness correlates with increased risk of a major cardiovascular event (Ref. 5 and 7, 8, 22, 23, 26, 28, 29, 30 and 32). The specific validation of Pulse Trace was done at St Thomas' Hospital and has been published (Ref.3, 6 and 9 ). These papers demonstrated: A simple linear relationship between the shape of the Digital Volume Pulse and that of the peripheral pressure pulse, which remains constant irrespective of the effects of hypertension or effects of vasodilatation produced by NTG and that the Stiffness Index (SI) parameter correlates with PWV the gold standard for arterial stiffness (see below)
It is stable, simple, easy to use device with a low Coefficient of Variation
In comparison to other methods to measure arterial stiffness and vascular tone Pulse Trace is the only one that is operator independent with a Coefficient of Variation equivalent or better than the other established techniques. This has been demonstrated in a number of independent studies (Ref. 9 to 11)
The Stiffness Index (SI) parameter correlates with the 'gold standard' measurement for arterial stiffness PWVcf
The Stiffness Index (SI) is calculated from the time it takes the reflected pressure wave to travel from the lower body back to the finger divided into the subject's height. Whilst many factors influence the volume pulse contour, arterial stiffness is the dominant factor. This was clearly demonstrated in a comparison of the 'gold' standard method of measuring arterial stiffness using the PWV (carotid - femoral) with the Pulse Trace SI parameter (Ref. 9 and 3). This paper and others show that SI is a measure of arterial stiffness. The link between arterial stiffness and the risk of a major cardiovascular event is well established and SI can be used to measure and monitor arterial stiffness in a simple, non-operator dependant, and reproducible manner.
The Reflection Index (RI) parameter measures vessel tone and can be used to assess endothelial function.
The Reflection Index (RI) is calculated as the % ratio of the height of the diastolic notch to the peak pulse height. In numerous studies it has been shown to correlate with vascular tone (large vessel diameter) and can be used as a bases for a non invasive test for endothelial function (Ref. 3, and 11 to 14, 24 ,25, 27)and in other studies where the disease process or drug action is known to modify vascular tone e.g. PIH (Ref. 15)
Bibliography
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